Herding dog breeds and their mixes, specifically those with the MDR1 genetic mutation, are highly sensitive to Imodium (loperamide). Affected breeds include Collies, Australian Shepherds, Shetland Sheepdogs (Shelties), Old English Sheepdogs, Border Collies, German Shepherds, and Longhaired Whippets.

What dogs are sensitive to Imodium?

Herding breeds like Collies, Australian Shepherds, and Shelties often carry the MDR1 gene mutation, making Imodium potentially dangerous. These dogs cannot properly process certain medications, allowing them to cross into the brain and cause serious neurological effects.

When should I not give my dog Imodium?

Some breeds of dogs, including Sheepdogs, Collies, and mixed breeds that include herding dogs, may be more sensitive to Imodium due to an MDR1 genetic mutation. Giving Imodium to these dogs may cause extreme sedation and should be avoided.

What dog breeds are affected by MDR1?

The MDR1 variant is most commonly found in herding breeds, including, but not limited to the following:

• Collies.
• Australian Shepherds.
• American Shepherds.
• German Shepherds.
• Shetland Sheepdogs.
• Old English Sheepdogs.

What anti-diarrhea medicine is safe for dogs?

While Imodium (loperamide) and Kaopectate/Pepto-Bismol (bismuth subsalicylate) are common over-the-counter options, you must consult your veterinarian first to determine the cause of diarrhea and ensure the correct, safe dosage, as these can be harmful for certain breeds (like Collies with the MDR1 gene) or underlying conditions. Other options include kaolin-pectin (Kaopectalin), but always get vet guidance for safe administration and to rule out serious issues like parasites or toxins.

You're Feeding Your Dog With Diarrhea WRONG (Home Treatment Vet Advice)

What do vets recommend for dogs with diarrhea?

Vets treat dog diarrhea with prescription meds like Metronidazole (Flagyl) for bacterial issues, Tylosin (Tylan), or sometimes Prednisone for inflammation, alongside probiotics, dewormers, bland diets (boiled chicken/rice), and fluids, but treatments vary by cause, ranging from dietary indiscretion to infections, often starting with supportive care like diet changes and probiotics before stronger meds.
 

What are the alternatives to Imodium for dogs?

• Kaolin-Pectin.
• Loperamide.
• Bismuth subsalicylate.
• Antibiotics.
• Probiotics.
• Dewormers.
• Other Diarrhea Medications for Dogs.

What are MDR1 in dogs' symptoms?

MDR1 often presents in young adulthood, only because this is most commonly when a dog is first exposed to a problem drug like high dose ivermectin or acepromazine. Symptoms arise after a dog has received an MDR1 problem drug or dosage, and can range from vomiting and diarrhea to lethargy, seizures, or coma.

What is the new name for MDR1?

The source of the resistance was traced back to P-glycoprotein, and, because of this, the gene encoding it was named Multidrug Resistance 1, or MDR1. Later, the gene name was changed to ABCB1, and both notations are still used today.

What is the leading cause of death for border collies?

In fact, your Border Collie's life span may even be cut short by one to three years! Cancer is a leading cause of death in older dogs. Your Collie will likely live longer than many other breeds and therefore is more prone to get cancer in his golden years.

When should Imodium be avoided?

You should not take Imodium (loperamide) if you have bloody/black stools, fever, severe abdominal pain, or diarrhea caused by bacterial infection (like dysentery) or ulcerative colitis, as it can worsen the condition; also avoid it with a history of heart rhythm problems, liver disease, ileus, or if pregnant/breastfeeding without a doctor's advice, and stop immediately if symptoms worsen or you develop abdominal swelling. Always consult a doctor if diarrhea lasts over 2 days, as the cause needs addressing.

How long does it take for Imodium to kick in for a dog?

You shouldn't give your dog Imodium for longer than two days without consulting your veterinarian. Imodium takes effect within a couple of hours. If you see no improvement or the issue persists for more than 48 hours, your vet will likely recommend alternatives.

Is MDR1 testing expensive?

Dog Multidrug Resistance 1 (MDR1) Test

The price of the Dog MDR1 Test starts from $69.

How much Imodium is toxic to dogs?

In dogs, doses of 1.25mg/kg/day to 5mg/kg/day produced vomiting, depression, severe salivation and weight loss3. In the experience of Veterinary Poisons Information Services, doses greater than 0.1mg/kg in collie breeds might produce toxic effects12.

What breeds have MDR1?

In addition to collies breeds, the MDR1 nt230(del4) has been described in other breeds, including Shetland Sheepdogs, Border Collies, Australian Shepherds, Miniature Shepherds, Old English Sheepdogs, English Shepherds, German Shepherds, White Swiss Shepherds, McNabs, Wällers, and Longhaired Whippets [8,9].

Is Heartgard safe for MDR1 dogs?

The FDA determined Heartgard is safe for dogs with the MDR1 mutation when used at label doses. For other formulations of ivermectin contact MDR1Caddie™ for dosing recommendations. At doses used to treat diarrhea, this drug will cause neurological toxicity in dogs with the MDR1 mutation.

Which drugs cause MDR1 reactions?

Drugs of concern for MDR1 mutations

• Certain anesthetic agents (butorphanol and acepromazine)
• Antiemetics (maropitant, ondansetron)
• Apomorphine.
• Grapiprant.
• Cyclosporine.
• Some chemotherapy agents. 3,6

How to test your dog for MDR1?

Testing a dog or cat for MDR1 is simple and quick, requiring only a DNA sample. DNA can be obtained from your pet's cheek cells using a swab or from your pet's blood.

What are the first signs of DM in dogs?

Initial signs include loss of coordination (otherwise called ataxia) in the hind limbs; swaying or wobbling when walking; rear feet knuckling over or dragging; and difficulty with walking up steps, squatting to defecate, or getting into the car.

Can MDR1 dogs have Pepto Bismol?

Mild cases of gastrointestinal (GI) distress in dogs can usually be addressed at home. Pepto-Bismol can be a suitable option when it is dosed appropriately. Overall, however, there are better, safer, and more natural alternatives to Pepto-Bismol when your dog has an upset stomach.

What is a safer alternative to Imodium?

Pepto-Bismol, an over-the-counter antacid with bismuth subsalicylate, treats not only diarrhea but also nausea, upset stomach, and indigestion. Kaopectate shares the same active ingredient as Pepto-Bismol and addresses similar symptoms. These alternatives work by slowing bowel movements and solidifying stools.

What foods will firm up dog poop?

To firm up dog stools, add fiber-rich foods like plain canned pumpkin, sweet potatoes, or cooked carrots, which absorb water and add bulk, or try a bland diet of boiled chicken and white rice for easily digestible protein and starch; probiotics and psyllium husk also help regulate gut health, but always consult your vet for persistent issues.
 

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