Rabies is still a significant global threat, causing approximately 55,000 to 70,000 human deaths annually, primarily in Asia and Africa due to dog bites. In the United States, it is rare in humans (1–3 cases/year) but remains common in wildlife, with thousands of cases reported annually in bats, raccoons, and skunks.

How common is rabies now?

Thanks to the coordinated efforts of human and animal health experts, fewer than 10 human deaths are reported each year in the U.S. While rabies is uncommon in humans, three out of four Americans live in a community where raccoons, skunks, or foxes carry this deadly disease.

When was the last case of rabies in the US?

In 2022, there was no human death due to rabies. In November 2024, a California art teacher died from rabies, about a month after being bitten by a bat she found in her classroom.

What is the deadliest virus on Earth?

Using the “case fatality rate” metric to determine what virus is the deadliest, rabies would likely come out on top. That's because, if an infection becomes symptomatic, rabies is fatal to humans in more than 99 percent of cases. Globally, approximately 59,000 people die from rabies every year.

Has anyone died from rabies in 2025?

Rabies is almost always fatal without postexposure prophylaxis (PEP). What is added by this report? In February 2025, CDC confirmed a fatal rabies case in a patient who had received a transplanted kidney from a deceased donor with undiagnosed rabies.

Rabies: One of the Most Deadly Viruses

How long until rabies kills a human?

Once rabies symptoms appear, death typically occurs within 7 to 10 days, usually from respiratory or cardiac failure, as the disease causes fatal brain inflammation (encephalitis); survival after symptoms start is almost unheard of, making immediate treatment after animal exposure critical during the incubation period (days to months) before the virus reaches the brain.

How likely am I to get rabies from a scratch?

Rabies is transmitted through saliva, so fortunately the chances of contracting rabies from a cat scratch are low. The only chance that it might be spread through a scratch is when scratching is accompanied by hissing and biting, which can aerosolize and transmit the virus to another individual.

Should I get a rabies shot just in case?

If you're exposed, it's important to head to your nearest emergency department (ED) for post-exposure prophylaxis, which includes wound care and a series of vaccines. Fortunately, the rabies vaccine is extremely effective. “You just need to get treatment soon enough,” Dr. Grogan says.

How quickly will I know if I have rabies?

Rabies symptoms usually appear 1 to 3 months after exposure, but the incubation period can range from a few days to over a year, depending on the bite's location (closer to the brain means faster onset), severity, and the person's age, with early signs like fever, headache, and tingling at the wound site progressing to anxiety, paralysis, and hydrophobia. Prompt washing of the wound and post-exposure prophylaxis (PEP) are critical to prevent the virus from reaching the brain.

Is it very rare to get rabies?

Rabies is a rare but serious infection that's usually caught from a bite or scratch of an infected animal. It's almost always fatal once symptoms appear, but vaccination and early treatment can prevent it.

How painful is rabies?

The first symptoms of rabies are similar to a flu-like illness—fever, headache, and general discomfort. Within days, the disease can progress to symptoms such as anxiety, confusion, agitation, abnormal behavior, delirium, and hallucinations. Once symptoms appear, rabies is almost always fatal.

Is rabies making a comeback?

Rabies, one of the world's deadliest but most preventable viral diseases, is making a troubling comeback across the United States. Health officials and veterinarians are sounding the alarm as outbreaks among wildlife surge in several states, and the number of human fatalities has reached its highest point in years.

Why is rabies 99% fatal?

As the virus moves to the central nervous system, progressive and fatal inflammation of the brain and spinal cord develops. Clinical rabies in people can be managed but very rarely cured, and not without severe neurological deficits.

Why can't we cure rabies?

There's no cure for rabies once it's moved to your brain because it's protected by your blood-brain barrier. Your blood-brain barrier is a layer between your brain and the blood vessels in your head.

Has anyone survived rabies without a vaccine?

It was initially attempted in 2004 on Jeanna Giese, a teenage girl from Wisconsin, who subsequently became the first human known to have survived rabies without receiving post-exposure prophylaxis before symptom onset.

What virus is 100 fatal?

Rabies virus has a characteristic bullet-shaped virion structure. Rabies virus infection in mammals is nearly 100% fatal if left untreated.

What is the most terrifying disease?

Ebola & Hemorrhagic Viruses

Its rapid progression and high fatality make it one of the most feared viruses in modern history. Outbreaks in Africa since 1976 have killed thousands. The virus's short incubation period limits travel but makes containment urgent.

What is the 10 day rule for rabies?

The 10-day observation period for a biting dog, cat, or ferret is a standard public health practice to determine rabies risk: if the animal remains healthy for 10 days after biting someone, it wasn't shedding the rabies virus in its saliva at the time of the bite, meaning the exposed person usually doesn't need rabies post-exposure shots (PEP). This quarantine ensures the animal is available for monitoring, preventing unnecessary euthanasia for brain testing and avoiding expensive PEP for the bite victim if the animal stays healthy.
 

Can we kiss a person who is taking the rabies vaccine?

No, patients who are undergoing preventative vaccination against rabies are not able to transmit the virus to others. The vaccine does not contain live virus but rather a killed form of the virus and is non-infectious.

Do I need a rabies shot if there was a bat in my house?

Yes, you likely need a rabies shot (post-exposure prophylaxis or PEP) if a bat was in your house, especially if anyone was sleeping, a child, or an impaired person was present, or if there was any direct contact (bite, scratch, even waking up with it in the room), because bat bites can be tiny and missed; contact your health department and doctor immediately to arrange for the bat to be tested and to start PEP if exposure is suspected. 

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